Click-based synthesis and proteomic profiling of lipstatin analogues.
نویسندگان
چکیده
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 44 شماره
صفحات -
تاریخ انتشار 2010